The Deficiency of Immunoregulatory T Cells in Children with Diabetes
Mellitus
Sedláková N.1, Praksová P.1, Pejchlová M.2, Kovářová L.3, Hrstková H.2, Michálek J.2,3
studentka Lékařské fakulty MU, Brno1 I. dětská interní klinika, FN Brno,2 přednostka prof. MUDr. H. Hrstková, CSc. Laboratoř experimentální hematologie a buněčné imunoterapie, FN Brno3 vedoucí doc. MUDr. R. Hájek, CSc. |
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Summary:
Serious defects in immunoregulatory T cell subsets of CD4+CD25+ T cells and NKT cells have
been reported recently in adults with type 1 diabetes mellitus (DM1). In this study, these T cell
subsets have been followed in children and adolescents with DM1, their healthy siblings, patients
with disturbed glucose tolerance and normal controls by flow cytometry. A statistically significant
decrease in immunoregulatory CD4+CD25+ T cell subset has been found not only in children
with DM1 but also in their healthy siblings and patients with disturbed glucose tolerance in comparison
to healthy controls. Patients with disturbed glucose tolerance as well as healthy siblings
of patients with DM1 are at higher risk for DM1 development and this can be explained by disturbed
immunoregulatory function of CD4+CD25+ T cells. No difference in NKT cell numbers among
the groups of children has been found.
Key words:
diabetes mellitus, children, immunoregulation, lymphocyte
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