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CZECH MEDICAL ASSOCIATION J. Ev. PURKYNĚ |
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Česky / Czech version | Vnitř. Lék., 50, 2004, No. 11, p. 852 - 857 |
High-sensitivity C-reactive protein - New Parameter in Cardiovascular
Risk Assessment Dvořáková A., Poledne R. Centrum experimentálního výzkumu srdce a cév, Laboratoř pro výzkum aterosklerózy Institutu klinickéa experimentální medicíny, Praha, vedoucí prof. Ing. Rudolf Poledne, CSc. |
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Summary: Elevated C-reactive protein concentration, measured by an ultrasensitive method (hsCRP), has
been proved to be a risk factor for atherosclerosis progression and its complications (myocardial
infarction and stroke) in otherwise healthy men and women. In patients with already diagnosed
atherosclerotic disease elevated concentration of hsCRP predicts prognosis. There are multiple
causes of elevated hsCRP concentration: metabolic changes (e.g. as a part of metabolic syndrome),
genetic background and chronic infections. Proinflammatory effect of adipose tissue in obese
individuals seems to play an important role, hsCRP levels correlate with markers of abdominal
obesity. Elevated hsCRP concentrations can be lowered both pharmacologically and by a lifestyle
change. This review covers current knowledge of pathophysiology of elevated hsCRP concentration
and possible use of this method in clinical medicine.
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