13 patients with intractable mesial temporal lobe epilepsy (7 women and 6 men, average age at neurosurgery was 34.9 years) underwent radiosurgical amygdalohippocampectomy with gamma knife (9 times at the left side, 4 times at the right side). Patients were examined using the neuropsychological battery before the radiosurgery and in average 27 months after it. The one patient has had no seizures, two has not changed, and in 10 of them the frequency of seizures decreased with different degree. Intellectual performance (WAIS-R), memory (WMS-R or WMS), subjective memory evaluation, social status, and psychosocial characteristics (questionnaire SUPOS, WPSI) including quality of life assessment (questionnaire DSF, ESI-55, QOLIE-89) were examined. No major differences among the patients were found. Four of themhad significant changes in memory; theirmemory quotient (MQ) was changed for more than 15 points, which is more than one standard deviation. In two patients the change represented improvement, in two of them injury. Retirement for invalidity became more frequent (3 before surgery, 10 after it). The group of patients will be furthers followed up.

        Key words: gamma knife, radiosurgery, amygdalohippocampectomy, mesial temporal lobe epilepsy, neuropsychology, cognitive abilities, psychosocial outcomes, quality of life