Objective: To evaluate subsequent pregnancy experience in patients following chemotherapy for malignant form of gestational trophoblastic disease. Design: Retrospective clinical study. Setting: Slovak Center of Trophoblastic Disease, Bratislava, Slovak Republic. Methods: There were evaluated subsequent pregnancy experiences in 38 patients after chemothe- rapy for malignant form of gestational trophoblastic disease registrated in Slovak center of gesta- tional trophoblastic disease. Histological and cytogenetical analysis of all placentas after deliveries and material from curettage specimens after miscarriages, abortions and ectopic preg- nancies were performed. Results: 11 women concieved following successful chemotherapy of gestational trophoblastic dise- ase became pregnant a total 19 times. Out of them there were 9 full-term deliveries, 2 spontaneous abortion, 1 ended in ectopic pregnancy and 7 pregnancies were termined in therapeutic abortion. Cytogenetical analysis was successful in 7 to 10 reproductive losses with normal karyotype in all analysed cases. Conclusion: Patients after successful chemotherapy of gestational trophoblastic disease have a normal reproductive outcome.

        Key words: gestational trophoblastic disease, choriocarcinoma, pregnancy, chromosomal and DNA