CZECH MEDICAL ASSOCIATION J. Ev. PURKYNĚ | |
Journals - Article | |
Česky / Czech version | Vnitř. Lék., 48, 2002, No. 12, p. 1142 - 1146 |
Metabolic Aspects of the Polycystic Ovaries Syndrome Svačina Š. III. interní klinika 1. lékařské fakulty UK a VFN, Praha, přednosta doc. MUDr. Štěpán Svačina, DrSc. |
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Summary: The author reviews the history of the term polycystic ovaries syndrome. He emphasizes the
importance of insulin resistance in this disease. According to more recent criteria for the definition
of the syndrome suffices the finding of hyperandrogenism, an irregular cycle (after elimination
of other classical causes of this condition) and insulin resistance. The frequency of the disease
varies in different populations up to 10 %. It is significantly associated in particular with type 2
diabetes and obesity. The molecular biology of the syndrome is obscure. The metabolic syndrome
as well as the polycystic ovaries syndrome have partly a genetic pathogenesis as well as an
environmentally induced participation caused by stress. The polycystic ovaries syndrome is nowadays
unequivocally an atherogenic syndrome and is a unit very close to Reaven’s metabolic
syndrome X or is part of this syndrome.
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