Several genes important in the etiopathogenesis of schizophrenia have been recently discovered. These genes are related to the development of the brain, synaptogenesis, and the glutamatergic neurotransmitter system. This summary article deals with the question of a reflection of schizophrenia genetic background in the premorbid personality and psychosocial variables of the affected subjects. Cognitive abnormalities, poor academic performance, anxiety, depression, social withdrawal, violence and substance abuse are the most frequently described premorbid characteristics of schizophrenia. Relationship of these symptoms to individual genes detected so far is discussed. It is meaningful to offer long-term follow-up, psychoeducation and psychotherapy to persons with supposed premorbid symptoms of schizophrenia in a routine clinical practice.

        Key words: schizophrenia, genetics, premorbid personality, psychoeducation.