Incidence of Modifiable Risk Factors of Spontaneous Intracerebral and
Subarachnoid Haemorrhages in the Olomouc Region. Prospective Study 1998–2000.
Part II. Non-metabolic Risk Factors and Combinations of Risk Factors
Herzig R.1, Vlachová I.1, Urbánek K.1, Křupka B.1, Gabryš M.2, Mareš J.1, Šaňák D.1,Schneiderka P.3, Buřval S.4
1Iktové centrum, Neurologická klinika FN a LF UP, Olomouc 2Neurochirurgická klinika FN a LF UP, Olomouc 3Oddělení klinické biochemie FN, Olomouc 4Radiologická klinika FN a LF UP, Olomouc |
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Summary:
Background and objective: In the etiopathogenesis of spontaneous intracranial haemorrhages (SICH)
a number of risk factors (RF) plays a part. The objective of the prospective study was to evaluate the
role of modifiable RF in different subtypes of SICH. Methods: The authors examined a group of 105
patients with SICH, incl. 88 intracerebral haemorrhages (ICH) and 17 subarachnoid/intraventricular
(SAH/IVH) ones. The incidence of the following non-metabolic RF and their combinations was investigated:
oral anticoagulant therapy and other coagulopathies, thrombocytopenia, salicylate treatment
and oral contraceptives, use of drugs, smoking, acute and chronic alcohol intake. The authors investigated
also the incidence of the mentioned non-metabolic RF in combination with metabolic RF (arterial
hypertension AH), diabetes mellitus/impaired glucose tolerance (DM/IGT), obesity, dyslipidaemia. For
evaluation of the statistical significance of results the χ2 test was used. Results: Combination of chronic
alcohol consumption and active smoking was more frequent in patients with SAH/IVH than in ICH – in
31.2% vs. 12.0% (p=0.053). Conclusion: Combination of chronic alcohol consumption and active smoking
in our population plays a significant part in the etiopathogenesis of SAH/IVH.
Key words:
spontaneous intracranial haemorrhage, spontaneous intracerebral haemorrhage, subarachnoid
haemorrhage, risk factors
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