Almost one third of population is affected by thrombocytopathy with platelet hyperaggregability. A lot of these individuals have coronary artery disease (CAD) and are treated with low doses of ASA (acetylsalicylic acid). Recent papers often report on ASA resistance (ASA-R). In general, ASA resistance occurs in 5–15% of population. Several communications reported the data on 70–80% of ASA resistance in persons with progressed ICH. Many factors account for it: smoking, NSA abuse, polymorphisms COX and IIb–IIIa, DM, dyslipidemia, stress, etc. A direct correlation between oxidative stress and the incidence of ASA-R (elevated synthesis of isopropanes with aggregation effect) is assumed. The aim of the present communication was to study a correlation between ASA resistance and oxidative stress in CAD patients. Methods: The study was performed with 298 individuals treated with 100 mg of ASA/day under the secondary prevention programme. The spontaneous platelet aggregability was examined as well as aggregability after induction CPG (cut-off for ASA-R spontaneous aggregability – 5%, CPG slope – 53%/min), AOPP and ultrasensitive CRP were determined. Results: 298 individuals (65% men, 35% women, mean age 64.8±9.8 years), secondary CAD prevention. ASA resistance was found in 43%, AOPP values was significantly increased in 13% (>100 µmol/l). No correlation was found between aggregation markers and AOPP/CRP concentration (even after stratification according to ASA-R). The incidence of ASA resistance correlated only with age (correlation coefficient 0.19, p < 0.0001). AOPP and CRP values were higher in men compared with women (94.2 µmol/l vs. 77.7 µmol/l, p < 0.05; 12.9 mg/l vs. 6.6 mg/l, p < 0.05). Conclusion: No direct correlation was found between ASA resistance and oxidative stress evaluated by AOPP in 298 individuals with CAD.

        Key words: ASA resistance, oxidative stress, advanced oxidation protein products (AOPP)