Objective: Study of antibodies against laminin-1 in IgG in patients with habitual abortion. Design: Prospective study. Methods: Commercial ELISA method for detection of IgG antibodies against laminin-1 in ovulatory cervical mucus, in sera in women with repeated spontaneous abortions, in sera in patients during spontaneous miscarriages. Results: Positive levels of antibodies against laminine-1 in IgG in sera were found in patients during spontaneous abortions, as to ovulatory mucus of infertile women in time out of pregnancy, we did not find any positivity, only in one serum sample in patient with three pregnancy losses in her history. Conclusion: Antibodies against adhesive molecule as laminin-1 presents, can participate during diagnosis of repated spontaneous miscarriages in context of neuro-endocrinne-immune dysregulation , which is not seen during physiological pregnancy.

        Key words: repeated spontaneous miscarriage, laminin-1, antibodies against laminin-1