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CZECH MEDICAL ASSOCIATION J. Ev. PURKYNĚ |
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Česky / Czech version | Vnitř. Lék., 48, 2002, No. 11, p. 1049 - 1053 |
Questionnaire Survey of the Tolerance and Undesirable Effects
of Clodronate (Bonefos) in Patients with Multiple Myeloma Laštůvková I., Adam Z. Interní hematoonkologická klinika Lékařské fakulty MU a FN Brno, pracoviště Bohunice, přednostaprof. MUDr. Jiří Vorlíček, CSc. |
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Summary: The tolerance of Bonefos was assessed by means of a questionnaire completed by 87 (76.3 %) of 114
addressed patients with multiple myeloma who use this drug for prolonged periods. Of 54 patients
treated by the oral form 50 % were quite free from complaints, and complaints associated with
more than half the administrations was reported by 7.4 % patients. Of 33 patients treated by
infusion 57.6 % were quite free from complaints and 9.0 % patients had complaints after more than
half the administrations. The most frequent undesirable effect reported by the addressed patients
were digestive complaints. The latter were reported by 47.3 % of the total number of patients who
had oral treatment and 42.4 % patients who had treatment by the i.v. route, although in both
groups this undesirable effect was as a rule observed in less than 50 % administrations of the
drugs. As this was not a placebo controlled trial (which in this case would not be possible for
ethical reasons), it is important to consider the fact that the etiological cause of complaints could
be any of the concurrently administered drugs incl. cytostatics and that the number of digestive
complaints caused by clodronate will be smaller. A total of 16.4% patients with the oral form and
18.2 % patients with the intravenous form reported paraesthesias. This emphasizes that it is
advisable or rather necessary to ensure calcium and vitamin substitution also in originally normocalcaemic
patients. The preference of a 800 mg capsule to two 400 mg capsules was statistically
significant.
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