We evaluated the effect of moxonidine (Cynt) 0,3 mg (n = 22) and 0,4 mg (n = 25) p.o. on the attenuation of haemodynamic response during laparoscopic cholecystectomy in comparison with clonidine (Catapresan) 150 mg i.v. (n = 23) and control group (n = 22). Compared to clonidine, moxonidine was not able to attenuate the rise in blood pressure during capnoperitoneum; however, both groups of moxonidine and clonidine shown less frequent occurrence of blood pressure readings over 175/105 compared to control group (p < 0.001). Other followed parameters (consumption of fentanyl, postoperative sedation, hypotension, bradycardia, nausea and vomiting) did not differ among groups. In conclusion, administration of clonidine in premedication before laparoscopic cholecystectomy provides better results, compared to moxonidine.

        Key words: capnoperitoneum – hypertension – clonidine – moxonidine