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CZECH MEDICAL ASSOCIATION J. Ev. PURKYNĚ |
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Česky / Czech version | Vnitř. Lék., 48, 2002, No. 8, p. 763 - 766 |
SEN Virus - Will There be another Letter in the Alphabet
of Viral Hepatitis? Husa P.1, Chalupa P.1, Husová L.2 1Klinika infekčních chorob Lékařské fakulty MU a FN Brno, pracoviště Bohunice, přednosta doc. MUDr. Pavel Chalupa, CSc. 2Interní gastroenterologická klinika Lékařské fakulty MU a FN Brno, pracoviště Bohunice, přednosta prof. MUDr. Petr Dítě, DrSc. |
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Summary: The SEN virus (SENV) is a small nonenveloped single-stranded DNA virus which is probably
a circovirus. By phylogenetic analysis it is possible to differentiate genotypes SENV A-H. The
pathway of transmission of infection is not known so far but the infection by this virus is frequent
in recipients of blood transfusions and liver grafts and in intravenous drug addicts. This suggests
possible parenteral transmission of infection. Other routes of transmission of the infection are
also possible as the virus can be detected also in a significant proportion of young subjects
without the risk of parenteral infection in the case-history. Whether SENV causes hepatitis has
not been proved unequivocally so far. The prevalence of this infection does not differ significantly
in patients with different liver diseases, acute or chronic viral or non-viral. SENV infection very
probably does not influence the course of chronic hepatitis C.
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