In this contribution publish the observation that addition of 10% L-arginin.HCl to the 2% Trusopt eye drops intensifies activity of antiglaucomatics with an important reduction of the normal intraocular pressure (IOP) in rabbits New Zeland white namely from 15 up to 240 minutes, compared with application of both substance alone. Size of the pupil was not affected. Based on our experimental resultsweassumethat this increasing activity of Trusoptmixture with amino acid L-arginin.HCl created a new metabolite. According to our observations this metabolite caused reduction of the humor aqueous production and together with the increased of the uveo-scleral outflow leads to the striking reduction of the IOP.

        Key words: IOP after instillation the amino acid 10% L-arginin.HCl. 2% Trusopt and mixture both of them