In this study the authors deal with general parameters of imaging radiodiagnostic methods (ultrasonography, computerized tomography and magnetic resonance) and they compare their reliability with the results gained at autopsy or biopsy of pathologically changed human tissues and organs with possible applicability of histochemical methods for the proof of enzymes, lipids and sugars, with special diagnostic importance of immunohistochemistry. Scanning and transmission electron microscopy in diagnostic practice shifts the possibilities of morphological research to subcellular and even to molecular level. The authors show the possible problems which the non invasive clinical imaging methods and morphological examinations can accompany. They come to the conclusion that the mutual symbiosis and combination of both approaches provide the most real and trustful results.

        Key words: imaging radiodiagnostic methods – ultrasonography – computerized tomography – magnetic resonance – autopsy – biopsy – histochemistry – electron microscopy