Background. Experience with diagnosis and results of the treatment cancer of the penis are comparatively sparse. We present our experience and treatment results of patients with this diagnosis. Methods and Results. The group of 286 patients were diagnosed and treated between 1981–2006 at the First Medical School, Charles University, Prague, Department of Urology , District Hospital Ústí nad Labem. and University Hospital Na Bulovce, Department of Urology, Prague. Average age of the patients was 55 year. In 93% of cases the disease originated from an untreated phimosis Squamous cell cancer was found in 91% of the biopsies. Organ preserving surgery was done in 108 patients. Interstitial brachytherapy Ir 192 was first used as organ preserving treatment modality for patients with SCC in Czech Republic. 106 inguinal lymphadenectomies were performed, in 41 cases in a modified form. For the patients with positive lymph nodes, chemotherapy as neoadjuvant or adjuvant treatment approach was indicated. Actinotherapy was indicated minimally. Treatment complications intra- or postoperative were minimal. From our cohort 79.7 % patients survived, 39.8 % of them survived more than 10 years. Conclusions. We recommended concentrating patients with this relatively rare disease to the special department with complete diagnostic and treatment care.

        Key words: cancer of the penis, phimosis-squamous cell cancer, interstitial brachytherapy, inguinal lymphadenectomy, chemotherapy, actinotherapy.