Molecular Mechanisms of Lithium Biological Action
Patočka J.1, Klár I.2, Strunecká A.3
1Katedra toxikologie, Vojenská lékařská akademie, Hradec Králové, Katedra radiologie, Zdravotně sociální fakulta Jihočeské univerzity, České Budějovice 2Desitin Pharma, s.r.o., Praha 3Katedra fyziologie a vývojové biologie, Přírodovědecká fakulta UK, Praha |
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Summary:
Lithium has the inhibitory effect on many enzymes and multiple effects on some physiological processes. Lithium
is also highly effective in the treatment of bipolar disorder, however, the mechanism of lithium action in the
treatment of this psychiatric disorder is still unknown. A number of lithium-sensitive enzymes and putative
important biomolecules have been proposed as potential targets of lithium action and these mechanisms are
discussed in this review.
Key words:
lithium, bipolar disorder, inositol monophosphatase, phosphoinositide signaling system, glycogen
synthase kinase 3β, Wnt signaling
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