Medullary thyroid carcinoma (MTC) accounts approximately for 8 - 10% of all thyroid malignities. In the localization diagnostics of the metastatic process or relapse of the disease in addition to sonography, CT examination and NMR, which however, fail in some cases, also a number of radiopharmaceuticals play a part. The authors evaluate radiopharmaceuticals used nowadays - 99m Tc (V)DMSA, 111 In pentetreotide, 131 I/ 123 I MIBG, 99m Tc, 111 In or 123 I/ 131 I labelled anti-CEA monoclonal antibodies or their fragments, 99m Tc MIBI, 201 Tl chloride and 18 F-FDG (fluorodeoxyglucose). Indications, sensitivity and specificity of different examinations are discussed.

        Key words: words: medullary thyroid carcinoma - Tc (V)DMSA - In pentetreotide - I/ I MIBG - 18 F-fluorodeoxyglucose (FDG)