Does Artificial Suckling Nutrition Pose a Risk of Atherosclerosis at the Adult
Age?
Steinerová A.1, Stožický F.2, Korotvička M.1, Racek J.3, Tatzber F.4
Medika-Centrum a.s., Plzeň1 vedoucí MUDr. A. Steinerová Dětská klinika LF UK a FN, Plzeň2 přednosta prof. MUDr. F. Stožický, DrSc. Ústav klinické biochemie a hematologie LF UK a FN, Plzeň3 přednosta prof. MUDr. J. Racek, DrSc. Reagenzien und Recycling, Klosterneuburg, Austria4 |
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Summary:
Atherosclerosis has acquired the character of epidemic in our century. The acknowledged factors
of atherosclerosis lately include the oxidation stress. Our workplace has been dealing with
oxidation stress factors for more than 10 years. Since 1998 we noticed a high titer of AboxLDL
antibodies in children, whose mothers could not practice breast-feeding and artificial nutrition
based on cow’s milk was necessary. This paper demonstrates that the presence of beta-casein in
cow’s milk is the cause of increased AboxLDL titer, especially the A1 variant of beta-casein. In the
experiment in pigs, however, we have not demonstrated any association between the high titer of
AboxLDL and the development of premature atherosclerosis.
Key words:
suckling nutrition, oxidation stress, antibodies against oxLDL, beta-casein, betacasein
variants, atherosclerosis risk
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