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CZECH MEDICAL ASSOCIATION J. Ev. PURKYNĚ |
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| Česky / Czech version | Čs. Patol., 34, 1998, No. 4, p. 142 - 148 |
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Inflammatory Stromal Reaction in Epithelial Neoplasias of the Uterine Cervix in Correlation with HPV Infection M. Tichý 1 , V. Tichá 1 , Z. Kolář 1 , S. Brychtová 1 , J. Bystroň 2 , L. Kotršová 3 , E. Hamšíková 4 , J. Dušek 1 , V. Vonka 4 1 Ústav patologie LF UP, Olomouc, přednosta prof. MUDr. J. Dušek, CSc. 2 Oddělení klinické imunologie FN, Olomouc, vedoucí doc. MUDr. E. Weigl, CSc. 3 Porodnicko-gynekologická klinika FN, Olomouc, přednosta prof. MUDr. M. Kudela, CSc. 4 Ústav hematologie a krevní transfuze, Praha, ředitel prof. MUDr. V. Vonka, DrSc. |
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Summary: 260 cases of women with epithelial neoplasias of the uterine cervix were studied: HPV infection was detected by DNA in situ hybridization and serology, simultaneously structure and intensity of stromal inflammatory reaction (SR) were evaluated (semiquantitatively) as well as standard clinical immunological parametres investigated by serology. Results proved the same character of SR in intraepithelial lesions and invasive carcinomas and the intensity of SR increasing in relati- on to the gravity of epithelial dysplasia. There was not found any significant difference in SR between cases with detected HPV infection and cases lacking it. Summarized immunological parametres were in limits of normal reference range.
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