Cleft lip and cleft palate are problems of great importance. The majority of cleft lips and palate are caused by the misdevelopment of mesoderm in facial region in second and third week of gestation. The main goal of the study was to evaluate the epidemiology of cleft lip and palate in East Slovakia and influence of environmental agents on the development of cleft lip and palate. The data were collected from epidemiological study performed by investigators among the population born with cleft anomaly in the period 1985–2000. Our conclusions concerning type of cleft and possible genetic and environmental influences were correlated to the literature. All of our results are pretty close to results published in literature

        Key words: clef lip and palate – plastic surgery – incidence – questionnaire