Objective: Analysis of contemporary knowledge of proteomics and its aplication in diagnostics of ovarian cancer and other malignant tumours. Design: Review article. Setting: Department of Gynecology and Obstetrics, 1st Faculty of Medicine, Charles University, Prague. Method: An overview of published data. Conclusion: Proteomics deals with the analysis of proteins present in the organism in normal and pathologic conditions. Protein expression is characteristic of particular types of cells and tissues. The main improvement of protein analysis in clinical practice is early diagnostics of oncological diseases and specifi cation of prognosis.

        Key words: proteomics, ovarian cancer