? Sarcoidosis, although normally regarded as a pulmonary disease, is, in its nature, a classical systemic disea¬se. From an ethiopathogenetic point of view, the diseases is characterized by non-caseated granuloma for-mation, which can involve almost all of the organs in the human body, some of them with clinical manifes-tation and some asymptomatically. In addition to organ involvement the disease also has immunopathologic and metabolic manifestations. Chronic fatigue is considered to be one of the most difficult of the sarcoido¬sis symptoms to treat. In generál, the acute disease with prominent intrathoracic involvement and often with spontaneous regression is prognostically the most favourable form of sarcoidosis. Chronic forms of the dise¬ase with prominent extrapulmonary manifestation, usually involving the heart or centrál nervous systém, háve much worse prognosis and can be fatal. The treatment modalities of sarcoidosis comprise mainly of corticosteroids, alternatively antimalaric drugs and immunosuppresives. The biological treatment, targeted against TNF-alpha mediated immunopathologic response, has been recently tried in some cases of the disease.

        Key words: words: sarcoidosis, granulomas, multiorgan involvement, prognosis, treatment.