![]() |
CZECH MEDICAL ASSOCIATION J. Ev. PURKYNĚ |
Journals - Article | |
![]() |
![]() ![]() ![]() ![]() ![]() ![]() ![]() |
Česky / Czech version | Vnitř. Lék., 48, 2002, No. 2, p. 142-146 |
Non-specific
Immune Response in Patients with Diabetic Foot Syndrome with Chronic Bacterial Infection Jirkovská A., Fejfarová V., Hosová J., Kalanin J., Stříž I., Skibová J.: Centrum diabetologie Institutu klinické a experimentální medicíny, Praha, přednostka prof. MUDr. T. Pelikánová, DrSc. Imunologické pracoviště Institutu klinické a experimentální medicíny Praha, přednosta MUDr. I. Stříž, CSc. Pracoviště lékařské statistiky Institutu klinické a experimentální medicíny, Praha, přednosta MUDr. P. Totušek |
|
Summary: Chronic bacterial ulcers infection is a frequent cause of non-healing diabetic foot. The major
factors of a non-specific immune response are phagocytic cells including polymporphonuclear
(PMN) leukocytes, and humoral systems (complement). PMN leukocytes remove microorganisms
by phagocytosis a part of it is intracellular killing and degradation in a process requiring energy
and associated with „respiratory burst“. The aim of our study was to assess non-specific immune
response in patients with diabetic foot syndrome and chronic bacterial infection. 30 patients
treated over one month with antibiotics for an infected diabetic foot in our foot clinic had
significantly lower values of „oxidative burst“ of PMN leukocytes in basal state (396 ± 228 vs. 574 ±
337, p < 0.05) in comparison with 25 matched healthy controls. There were no significant differences neither in the count of active phagocyting PMN leukocytes and their initial phagocytic activity nor in the humoral component of non-specific immunity (in circulating immunocomplexes, C3
and C4 components of complement) between both groups. The results of our study show a slightly
altered non-specific immune response in patients with diabetic foot syndrome and chronic bacterial infection.
|
|
Order this issue
|
BACK TO CONTENTS | ||
| HOME PAGE | CODE PAGE | CZECH VERSION | |
© 1998 - 2008 CZECH MEDICAL ASSOCIATION J. E. PURKYNĚ |
Created by: NT Servis, s.r.o., hosted by P.E.S. consulting, s.r.o. |
WEBMASTER |