At a pre-operation examination of a 75-year old patient there has by chance been found anemia and paraproteinemia. Subsequently there was diagnosed multiple myeloma - Kahler's disease. Five cycles of classical MOCCA chemotherapy (cyclophosphamide, vincristine, CCENu, mephalan, prednisone) without any autologous or allogenic bone marrow transplantation. In the course of therapy there was marked clinical improvement and a decrease in paraprotein. This treatment is suitable in patients over 65 years of age with a gradual course of the disease.

        Key words: multiple myeloma - high-dose chemotherapy - autologous transplantation.