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CZECH MEDICAL ASSOCIATION J. Ev. PURKYNĚ |
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| Česky / Czech version | Vnitř. Lék., 48, 2002, No. 1, p. 3-7 |
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Big Endothelin and Chronic Cardiac Failure Špinar J., Špinarová L., Vítovec J., Ludka O., Hubená G., Tomandlová M., Tomandl J II. interní klinika FN u sv. Anny, Brno, přednosta doc. MUDr. Jiří Zicha, CSc. I. interní kardio-angiologická klinika FN u sv. Anny, Brno, přednosta prof. MUDr. Jiří Toman, CSc. Katedra biochemie LF MU, Brno, přednosta doc. MUDr. Vladimír Palyza, CSc. |
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Summary: In a group of 124 patients the authors investigated the importance of assessment of plasma levels
of big endothelin and endothelin 1 in patients with chronic heart failure as compared with other
currently used non-invasive parameters. A six fold increase of plasma levels of both substances
was found in patients in functional class NYHA IV as compared with patients in class NYHA II-III.
But even patients in the milder stage of NYHA had twice as high values as compared with the
standard of the healthy population. Similarly patients with interstitial pulmonary oedema had
a twice as high level of both parameters as compared with patients who had a normal finding on
X-ray or merely a redistribution of the pulmonary vascularization. The sensitivity of assessment
of plasma levels is such that this examination could become part of the basic diagnosis.
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