Objective: Analysis of the issue of laparoscopy on the intra and post-operative immune changes. Subject: Review article. Setting: Department of Obstetrics and Gynecology, Regional Hospital Kladno. Subject and Method: Review of published facts with regard to impact laparoscopic surgery on immune function. Conclusion: The impact of surgery on the intra and post-operative immune, hormonal and inflammatory response is significantly less after laparoscopy than with an open approach.

        Key words: laparoscopy, immune system, CRP, cytokines, gynecologic surgery