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CZECH MEDICAL ASSOCIATION J. Ev. PURKYNĚ |
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Česky / Czech version | Vnito. Lék., 46, 2000, No. 10, p. 689 - 692 |
Effect of Alendronate Treatment on Bone Turn-
over - Results of a Multicentre Study Payer J. jun. 1 , Killinger Z. 1 , Masaryk P. 2 , Tomková S. 3 , Kmeeová Z. 4 , I. interná klinika Fakultnej nemocnice, Bratislava, prednosta prof. MUDr. I. Iuriš, DrSc. 2 Výskumný ústav reumatických chorôb, Piešany, vedúci prof. MUDr. J. Rovenský, DrSc. 3 Nemocnica VSŽ, Košice - Šaca, riadite3 MUDr. J. Vaneík, CSc. 4 Interné oddelenie NsP F.D. Roosevelta, Banská Bystrica, vedúci MUDr. M. Kme, CSc. 5 Fakultná nemocnica L. Pasteura, Košice, riadite3 MUDr. V. Pramuk 6 Ortopedické oddelenie NsP, Dolný Kubín, vedúci MUDr. J. Reguly 7 Ortopedické oddelenie NsP J.A. Raymana, Prešov, vedúci MUDr. J. K3oc 8 NsP MV SR, Bratislava, riadite3 doc. MUDr. I. Hanták, CSc. |
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Summary: Sodium alendronate is a bisphosphonate of the IInd generation with a strong amtiresorptive
effect. Its favourable effect on reduction of the incidence of vertebral and non-vertebral fractures
was repeatedly confirmed. The objective of the multicentre study was to evaluate the effect of
administration of 10 mg of sodium alendronate combined with 1000 mg of elemental calcium
administered in the course of three months on the N-terminal telopeptide(NT x) a sensitive mar-
ker of bone resorption.
The group comprised 275 postmenopausal women with densitometrically confirmed osteoporosis.
After three months treatment a 53 % decline of NT x values occurred as compared with baseline
values. This finding confirms the favourable effect of sodium alendronate on bone remodelling.
A decline of the concentraton of bone markers is one of the good predictors of the effectiveness of
treatment focused on reduction of atraumatic osteoporotic fractures.
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