After the initial enthusiasm for fluorides in the treatment of osteoporosis there was a regression after some time and a „campaign“ against fluorides. Recently in particular after the introduction of monofluorophosphate instead of NaF there is a revival of the use of fluorides in the treatment of osteoporosis, along with Ca, vitamin D and exercise as the classical combination of four. This can be supplemented by HRT in women,thyrocalcitonin, alendronate and other drugs with indivi- dual consideration of the optimal combination of these drugs. Also in future fluorides remain the foremost representative of the group of agents stimulating new formation of bone.

        Key words: Monofluorophosphate - Calcium - Vitamin D - Exercise - Classical combination of four.