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CZECH MEDICAL ASSOCIATION J. Ev. PURKYNĚ |
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Česky / Czech version | Vnitř. Lék., 50, 2004, No. 4, p. 282 - 285 |
Serum Leptin in Heroin Addicts, the
Influence of One Year Methadone Maintenance Treatment Wilczek H., Haluzík M., Svobodová J., Pařízková J. III. interní klinika 1. lékařské fakulty UK a VFN, Praha, přednosta prof. MUDr. Štěpán Svačina, DrSc. |
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Summary: Background and aim: The aim of the study was to explore the influence of heroin addiction and
one year methadone maintenance treatment respectively on serum leptin levels. Methods and
results: 14 heroin addicted subjects (9 men and 5 women) with average age 27.1 years (variation 22
- 38 years) and 17 control healthy subjects were included into the study. Mean duration of heroin
addiction was 9 years The subjects were treated for one year with mean daily dose of 90 mg of
methadone. Serum leptin levels were measured by enzymoimmunoassay, the rest of the biochemical
parameters was measured by standard laboratory methods. Body Mass Index (BMI) was calculated
by conventional method (kg/m2). Statistical analysis was performed using t test and paired t
test. Serum leptin levels in heroin addicts (7.08 ± 2.80 ng/ml) did not significantly differ from those
of control group (6.10 ± 1.23 ng/ml). One year of methadone maintenance treatment significantly
increased serum leptin levels to 12.10 ± 3.17 ng/ml vs control group (< 0.05). The same was true for
BMI which increased significantly from basal 21.47 ± 2.54 to 24.61 ± 2.82 (< 0.05). Conclusions:
Long term addiction to heroin did not change serum leptin levels as compared with control
group. One year of methadone maintenance treatment significantly increased serum leptin levels
as well as BMI values. We suggest that the increase in serum leptin levels could be explained by
the restoration of hypopituitary-hypothalamo-adrenal and/or hypopituitary-hypothalamo-gonadal
axis by methadone maintenance treatment. Alternatively, the improvement of nutritional status
with subsequent decrease in the infectious complications may be involved.
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