Objective: The aim of the study was to review health state in postmenopausal women with long- -term hormone replacement therapy and compare it with health state of control group without hormone replacement therapy. We focused on metabolic estrogen-defi ciency syndrom and its in- fl uence on risk of cardiovascular disease, risk of osteoporosis and memory dysfunction. Design: Epidemiology study. Setting: Department of Obstetrics and Gynecology, University Hospital, Hradec Králové. Methods: Pursuant to clinic and laboratory investigation we evaluated blood pressure, BMI, lipid profi le, blood sugar, CRP and homocystein in women with EPT, ET and compared the data it with controls. Due to dual X-ray absorptiometry we determined bone mineral density and by the memory quiz we evaluated memory function in examined postmenopausal women. Results: Our results indicate that use of hormone replacement therapy in postmenopausal women may be of benefi t in cardiovascular risk factors, especially with better plasma lipid profi le, blood sugar, atherogenity index, BMI and diastolic blood pressure. We found protective role of HT on decrease of bone mineral density in lumbal spine. We didn‘t prove this infl uence in hip. There is no evidence of HT infl uence on memory dysfunction, but we found, that culture and social life of older women in East Bohemia region is at low level. We did not register any heart attack, stroke and breast cancer under long-term treatment. Conclusion: Women with hormone replacement therapy have less of cardiovascular risk factors and better status of mineral bone density than women in control group.

        Key words: menopause, hormone replacement therapy, cardiovascular risk factors, osteoporosis