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CZECH MEDICAL ASSOCIATION J. Ev. PURKYNĚ |
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Česky / Czech version | Vnitř. Lék., 47, 2001, No. 6, p. 381-386 |
Apoptosis, its Mechanisms and Medical Value.
Part I. Definition of Apoptosis and its Mechanism on the Cell Level Novosad J., Kodydková K., Krejsek J Ústav klinické imunologie a alergologie Lékařské fakulty UK Hradec Králové, přednosta prim. MUDr. Otakar Kopecký, CSc. |
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Summary: Apoptosis is a one example of genetically-regulated cell death. It is characterized by the phylogenetically highly conserved activation of specific genes and proteins followed by energy-consuming proteolytic autodestruction. Apoptosis seems to be physiological and highly selective
mechanism to eliminate either old or injured cells in organisms. It is in contrary to mitosis.
A highly complex combination of various stimuli both extracellular and intracellular origins is
required for induction of apoptosis together with preserved oxidative phosphorylation.
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