Authors present results of series of experiments focused to influence the IOP by antiglaucomatics in rabbits (New Zealand White) with physiological IOP. Adding of the 10% amino acid L-arginin.HCl to the 0.005% Xalatan eye drops intensifies activity of antiglaucomatics resulting in 9.5% average reduction of the IOP in a four-hour experiments (with maximum in 15th min. - 19.3%), compared with application of both substances alone. Size of the pupil was not affected. Based on our experimental results we assume that the increased activity of the 0.005% Xalatan mixture with 10% amino acid L-arginin.HCl created a new complete metabolite – „bio-antiglaucomaticum“. According to our observations this metabolite caused increase of the uveo-scleral outflowleading to the striking reduction of the physiological IOP in rabbits.

        Key words: IOP after local application of the amino acid 10% L-arginin.HCl and 0.005% Xalatan mixture in experiments. New metabolite – „bio-antiglaucomaticum“ and the physiologic IOP in rabbits