Seroconversion rates of hepatitis B vaccination with increasing antigen doses, in 77 haemodialysis (HD) patients were studied in randomly divided two groups. The first group received the standard 20 g recombinant HBsAg (rHBsAg) dose, and the second group 40 g at the 0, 1 st and 2 nd months of HD. At the end of the study, there were no statistically significant differences between the two groups in the response rates of protective antibody, but the response was always higher in the second group. On the other hand, strong positive antibody response (100 mIU/ml) according to dates of each dose were as 7.4 %, 13.1 %, 28.9 % and 42.2 % in the first group and 50.0 %, 50.0 %, 60.0 % and 52.9 % in the second group respectively, and there were statistically significant differences between the two groups in the first thr ee months. We concluded that vaccination with higher antigen doses resulted in a stronger antibody response in the early period in our HD patients. No HBV infection was observed in these two groups in the study period.

        Key words: haemodialysis, HBV-vaccination, immunity