Cardiotoxicity of Antitumorous
Treatment
Horáček J.1,2, Pudil R.2, Tichý M.1,2, Jebavý L.1,2, Slováček L.1,2
1Katedra válečného vnitřního lékařství Vojenské lékařské akademie J. E. Purkyně, Hradec Králové 2II. interní klinika Fakultní nemocnice, Hradec Králové |
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Summary:
Cardiotoxicity is a serious and relatively frequent complication in patients treated for cancer. Antitumorous
treatment can cause a number of undesirable cardiac side effects, such as arrhythmias,
myocardial ischaemia, sudden death and heart failure. Cardiotoxicity can manifest anytime during
treatment and anytime after its termination. Late cardiotoxicity of anthracyclines, which can manifest
as chronic heart failure more than one year after termination of the treatment, is one of the most serious
problems. In viewof indisputable success of antitumorous treatment recently, the issue of cardiotoxicity
becomes more and more relevant. The authors review the most frequent cardiac complications of
antitumorous treatment. They emphasize the cardiotoxicity of anthracyclines and its derivatives,
because they represent the greatest risk.Furthermore, they reviewthe cardiotoxity of other cytostatics,
immunomodulators, radiotherapy and cardiac complications associated with transplantation of haematopoietic
cells.
Key words:
cardiotoxicity, cytostatics, immunomodulators, radiotherapy, transplantation of haematopoietic
cells
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