Cystic fibrosis is a serious genetically determined disease, which significantly decreases life quality and expectancy. Since a causal therapy is still nonexistent, it is necessary to direct the effort to early detection during the fetal period of life. DNA analysis is the main tool in prenatal diagnostics, but it has not been generally applied so far. In the present case report the authors draw attention to the fact that diagnostic imaging methods may detect some symptoms, which arise suspicion for cystic fibrosis defect (increased reflectance of the bowel in ultrasonography, lacking image of gall bladder in ultrasonography and magnetic resonance, improved quality in differentiation of gastrointestinal tract imaging by magnetic resonance). The imaging methods may therefore become significant elements for indication of costly DNA examination of the fetus. The case report of a 33-years old woman is conspicuous because of being the first so far published case of cystic fibrosis affection of the fetus, where the pathological changes were confirmed by magnetic resonance imaging.

        Key words: ultrasound in prenatal diagnostics – cystic fibrosis – ultrasound diagnostics