Objective: The aim of this study was to evaluate fibrin sealing in management of premature rupture of membranes after amniocentesis in early second trimester. Design: Case report. Setting: II. gynekologicko-pôrodnícka klinika LFUK NsP Ružinov, Bratislava; Department of Ob- stetrics and Gynecology, Spectrum Health – Blodgett Campus, Grand Rapids, USA. Subject and Method: In this case report authors report the use of fibrin sealant (Tissucol KIT, Immuno, A) in management of premature rupture of membranes after genetic amniocentesis. The sealing was performed in 19 + 0 week of pregnancy, 15 days after amniocentesis. The pregnancy was terminated by caesarean section in 34-th week, 98 days after sealing. The newborn was in stable condition, without clinical or laboratory signs of infection. No sceletal deformities or ad- verse efects of fibrin sealant were observed. Neurological examination in 3 month of age evalua- tes the psychomotorical development as normal. Conclusion: We consider the perinatal outcome of this pregnancy as positive.

        Key words: fibrin sealant, preterm rupture of maembranes, amnicentesis, Tissucol