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CZECH MEDICAL ASSOCIATION J. Ev. PURKYNĚ |
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Česky / Czech version | Vnitř. Lék., 47, 2001, No. 10, p. 671-678 |
Prevalence of Infection with Hepatitis G
Virus in Haemodialyzed Patients and Coinfection with Viruses of Hepatitis B and C Klusoňová H., Plíšková L.,Palička V., Fixa P. UK Praha, Farmaceutická fakulta, Hradec Králové, katedra biologických a lékařských věd, vedoucí doc. RNDr. Vladimír Semecký, CSc. Ústav klinické biochemie a diagnostiky FN, Hradec Králové, přednosta prof. MUDr. Vladimír Palička, CSc. I. interní klinika FN, Hradec Králové, přednosta doc. MUDr. Miloslav Pleskot, CSc. |
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Summary: The group of infectious agents causing viral hepatitis was extended by another virus the detection of which was published in 1995. This virus is described as virus of hepatitis G (HGV) or GBV-C
virus and is included among RNA viruses family Flaviviridae. Detection of HGV is based on
reverse transcription with subsequent amplification of the viral nucleic acid by means of a polymerase chain reaction. The authors examined sera of 82 chronically haemodialyzed patients incl.
22 (26.8 %) HGV RNA positive ones, whereby coinfection with HBV was proved in 3 specimens
(13 %). In 6 HGV RNA positive samples anti-HCV positivity was found (27 %), incl. one sample
where HCV RNA positivity was proved (4.5 %). Raised transaminase activity was found only in
three patients with HGV RNA positivity (13.6 %). From the presented results ensues that haemodialyzed patients are a high risk group for HGV infection.
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