Aim of the Study: To assess the changes of hemocoagulative parametres induced by ICP from the view of posssible affection of the hemostasis. Seating: Department of Obstet. Gynecol. 2nd Medical School Charles University and Teaching Hospital Motol, Prague, Institute of Haematology and Blood Transfusion Prague. Methodology: 20 blood samples of the pregnant with severe signs of ICP underwent the precise hemocoagulative analysis. The control group was composed from 12 women with physiological course of pregnancy comparable in terms of gestational week, age and parity. Results: The routine hemocoagulative tests did show any statistical significant difference between both groups of examined women. The statisticaly significant elevation was found in women with ICP in factor VIII (fVIII:C), vWf and in the serum levels of fibrinogen. The elevated levels of fibrinogen did not influence the function of platelets and even the analysis of fibrinogen itself did not show any significant differences. Clinically assessed peripartal blood loss did not deviate from average of loss during the spontaneous labor of healthy women. Conclusions: The changes in hemocoagulative parametres in patients with ICP do not increase the risk of thromboembolic events during pregnancy and labor. We also did not approve the risk of the higher peripartal blood loss in these patinets.

        Key words: intrahepatic cholestasis of pregnancy, hemocoagulative parametres, peripartal blood loss