Objective: To present a review of literature and to analyse a clinical retrospective series of pa- tients with granulosa cell tumor. Design: Retrospective study and review. Setting: Department of Obstetrics and Gynaecology, First Faculty of Medicine, Prague, Czech Republic. Methods: Retrospective analysis of age, stage, surgery, radiotherapy and chemotherapy, survival curve, number of recurrences and time to recurrence. Literature and information database (Med- line 1997-1999) review. Results: In a group of 43 patients the median of age was 53.5 years. 83.7% of cases were in a stage I. There were two duplicite tumors in a series. Conservative surgery was performed in 9/43 cases, 5 of them were reoperated on. The most frequent chemotherapy regimens were platinum-cyclo- phoshamide and BEP (bleomycin, etoposide, platinum). The 5-year overall survival was 86% and specific survival 90.7%. There were 3/43 recurrences, median time to recurrence was 22 months. Conclusion: A good prognosis of a patient with granulosa cell tumor requires a precise histopa- thologic examination, an adequate surgery and a comprehensive clinical analysis of a case to evaluate an indication of adjuvant therapy. Concentration of patients in oncogynaecological cen- tres is advisable. A careful follow-up because of a risk of late recurrences is necessary.

        Key words: granulosa cell tumor, ovary