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CZECH MEDICAL ASSOCIATION J. Ev. PURKYNĚ |
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Česky / Czech version | Vnitř. Lék., 48, 2002, No. 3, p. 177-181 |
Detection of TT Virus DNA in
Liver Transplant Recipients with Cryptogenic Cirrhosis Horváth R., Studeník P., Benedík J., Dendis M., Černý J.: Centrum kardiovaskulární a transplantační chirurgie, Brno, ředitel prof. MUDr. Jan Černý, CSc. |
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Summary: The possible causative role of novel TT virus in liver diseases has been intensively studied in
regarding its hepatotrophy, ability to cause persistent infection and worldwide prevalence. The
aim of this study was to estimate the prevalence as well as the clinical importance of TTV in
a normal healthy population group in the Czech Republic and in a group of liver transplant
recipients diagnosed with cryptogenic cirrhosis.
Polymerase chain reaction (PCR) detected the DNA of TT virus in 68 % (13/19) of samples isolated
from peripheral blood leukocytes and in 21 % (4/19) of plasma samples in the liver transplant
group. The viral DNA was detected only in 11,8 % (4/34) of leukocytes and in no plasma sample
from the healthy population control group. All patients included in this study had good liver
function and had no complications during the postoperative period.
The prevalence of TTV DNA detection in healthy control group in Czech republic is similar to the
rates reported in European and North American countries. Significant difference was proved
between the prevalences of TTV in the groups of healthy controls and liver transplant recipients
with cryptogenic cirrhosis. However, no association of TTV infection with possible postoperative
complications could be found.
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