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  Česky / Czech version Čes. a slov. Neurol. Neurochir., 67/100, 2004, No. 6, p. 445–449.
 
Central nervous system metastases in patients with breast cancer: 15 cases report and review of the literature 
Gokce M. 

Department of Neurology, Medical School, University of Kahramanmaras Sutcu Imam, 46050, Kahramanmaras, Turkey
 


Summary:

       Central nervous system (CNS) metastasis is one of the most dreaded complications in patients with systemic cancer. The focus of this work was to determine neurological findings in CNSmetastases from breast cancer. In this retrospective study over a sixteen months period, 258 patients with systemic cancer were seen on consultation and among them charts of 32 patients with breast cancer were reviewed. 15 of the 32 patients having central nervous system metastases were assessed for the following: age, reasons of consultant, neurological signs, length of time between primary systemic diagnosis and neurological involvement, localization of the CNS metastasis, and other organs metastases. The average age, and the length were 48.4 years, 22.8 months respectively. The reasons of consultation were highly variable and included, back pain (5/15), headache (3/15), seizure (3/15). The signs were also variable and included, hemiparesis (3/15), paraparesis (3/5), postictal state (2/15). Localization of the metastases included brain or brain stem (8/15), spinal cord (6/15) and meninges (1/15). 10/15 patients had other organ metastases as weel. Nearly half of the consultation in these patients were related with CNS metastases. Most of them associated with other organs metastases.

        Key words: neurological consultation, central nervous system metastasis, breast cancer
       

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