Significance of Serum Antibodies ANCA,
ASCA, ABBA in Diagnostics of Idiopathic Intestinal Inflammations
1Pintér M., 1Pintérová Kolesárová M., 2Drahošová M., 1Rejchrt S., 1Douda T., 1Tachecí I., 1Kopáčová M., 1Bureš J.
1II. interní klinika LF UK a FN a Subkatedra gastroenterologie, Hradec Králové 2Ústav klinické imunologie a alergologie LF UK a FN, Hradec Králové |
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Summary:
Background. Crohn’s disease and ulcerative colitis still remain a heterogeneous group of diseases with
an unclear aetiology. Serologic methods play important role in their diagnosing though there is still not
an ideal marker. We tried to determine the importance of serological testing of ASCA IgA, IgG, ANCA,
ABBA antibodies in patients with ulcerative colitis and Crohn’s disease.
Methods and Results. ASCA IgG, ASCA IgA, ANCA, ABBA antibodies and C-reactive protein were
detected by indirect fluorescence assay. ASCA IgA, ASCA IgG, ABBA, ANCA were examined in 40
patients (28 Crohn’s disease, 12 ulcerative colitis, 32 health controls). Specificity of ASCA IgA, IgG in
CD patients was high (both 96.2%), specificity ANCA in UC 100%. ABBA antibodies had low sensitivity
and specificity in both diseases. Combination of ASCA, ANCA, ABBA makes the specificity higher.
Conclusions. We showed the importance of combination ASCA, ANCA with ABBA antibodies to
improve the serological diagnosing of IBD.
Key words:
Crohn’s disease, ulcerative colitis, ASCA, ANCA, ABBA.
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