Late Relapse of Hodgkin´s
Disease 20 years after Diagnosis. Report of two Cases and Literature Overview
Marková J., Maaloufová J., Stříteský J., Feltl D. , Kozák T.
Oddělení klinické hematologie FN Královské Vinohrady Praha, přednosta prim. MUDr. T. Kozák Ústav patologie FN Královské Vinohrady, Praha, přednosta doc. MUDr. V. Mandys, CSc. Ústav radiační onkologie FN Bulovka Praha, vedoucí lékař MUDr. V. Stáhalová |
|
Summary:
Most patients with Hodgkin’s disease (especially early stage disease) are successfully treated
using modern treatment modalities. Disease relapse usually occurs within the first three years
after initial therapy. Late relapses of Hodgkin’s disease, occurring after 10 years or even later, are
rare (0,6 % of cases only). Their biological behaviour is different from that of early relapses,
resembling primary disease. The question whether very late relapses represent a second primary
disease in patients with a genetic predisposition to Hodgkin’s disease rather than a relapse of the
original disease remains the subject of much discussion.
We report here two cases of very late relapses of Hodgkin’s disease, occurring twenty years after
initial treatment. Both patients were now treated by intensified chemotherapy, escalated BEA-
COPP. In one case, this was followed by radiotherapy of the residual tumor (40 Gy). Both patients
are in complete remission.
Key words:
Hodgkin’s disease - Late relapse
|
