Presented review article brings the history of pancreatic transplantation in experiments and in the clinical treatment of diapbetic patiens. Surgical methods and effects of successfull combined pancreatic transplantation or transplatation of pancreatic transplantation alone on the metabolism of diabetic patiens and on the micro- and macrovascular complications are discussed. Evaluation of the method in the Czech Republic and in the world is presented.

        Key words: pancreatic transplantation, micro- and macrovascular complications.