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  Česky / Czech version Anest. intenziv. Med., 14, 2003, č. 6, s. 259–261
 
Levobupivacaine – Dosing Scheme in Paediatric Anaesthesia 
Mixa V. 

Klinika anesteziologie a resuscitace, UK, 2. LF a IPVZ, FN Motol, Praha, přednosta doc. MUDr. K. Cvachovec, CSc.
 


Summary:

       Regional anaesthesia is increasingly used in combined anaesthesia and for continuous postoperative analgesia. Next to bupivacaine, its levorotatory enantiomer – levobupivacaine – has been recently used more frequently. The efficacy of this new local anaesthetic drug is comparable with that of bupivacaine, however, its neurotoxicity and cardiotoxicity are significantly lower. Therefore, levobupivacaine seems to be a suitable anaesthetic drug for newborn babies and small children in which, in case of inaccurate administration, the risk of fatal complication is quite high. In the article we present a survey of dosage of levobupivacaine for paediatric patients. These data have only been sporadically reported so far. Drawn-up survey of dosage of levobupivacaine has been based on evaluation of data available in literature and our own experience. Maximum single dose for caudal and lumbar block is 2 mg/kg and 1.25 mg/kg for thoracic block.The continuous regimen dosage is based on the following scheme: 0.2 mg/kg/hour for newborns and 0.3–0.4 mg/kg/hour for older children. The citied authors differ slightly in doses and concentrations of the local anaesthetic used for the respective levels of access into the epidural space. The opinion prevails that administration of levobupivacaine to children of all age categories is based on approved indications for bupivacaine.

        Key words: regional anaesthesia of children – levobupivacaine – cardiotoxicity – neurotoxicity – dosage of levobupivacaine in children
       

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