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CZECH MEDICAL ASSOCIATION J. Ev. PURKYNĚ |
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Česky / Czech version | Vnitřní lékařství, 46, 2000, č. 9, s. 549 - 550 |
Lipid Disorders after Organ Transplantations Kuman M. Centrum kardiovaskulární a transplantační chirurgie, Brno, přednosta prof. MUDr. J. Černý, CSc. |
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Summary: Transplantations are a routine method of treatment of chronic and acute organ failure. Changes
in the therapeutic strategy led to improvement of organ and patient survival immediately after
transplantation and during the early post-transplantation period. Medium-term and long-term
results of organ survival improved less markedly. Chronic dysfunction and death are the most
frequent causes of loss of a transplanted organs one year after transplantation. Chronic dysfun-
ction has immunological and non-immunological causes. An important risk factor is hyperlipidae-
mia. Therapy must be started as soon as possible. It threatens the patients prognostically more
than the normal population. Dietetic treatment and optimal immunosuppression are essential
therapeutic steps which have a favourable effect on the general prognosis. A great hope in trans-
plantology are statins. They have not only a positive effect on blood lipids but also an immunu-
suppressive and antiproloferative effect which is very favourable for the prevention of
transplantation vasculopathies. Most probably their group effect is involved. Statins combined
with classical immunosuppressive preparations reduce the incidence of acute rejections. The
effect on lipid levels, the frequency of rejections and development of vasculopathies makes statins
important adjuvant preparations in transplantology.
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