Purpose:To observe the long term success of antimetabolites used in glaucoma filtering surgery in eyes with high risc of failure. Material and method:Two groups of patients undergone trabeculectomy with the use of antimetabolites 5-Fluorouracil (5-FU)and Mitomycin (MMC)are included in this retrospective study.5-FU was administered postoperatively 1-10 times in the dose of 5 mg/ml in subconjunctival injection on 32eyes.Follow up time ranged from 8 months to 9 years.Mitomycin C was administered intraoperatively in the dose of 0,2mg/ml,on subconjunctival sponge with application time from 3 to 5 minutes on 15 eyes.Follow up time ranged from 7 month to 4,5 years. Results:Intraocular pressure (IOP)before operation with the use of 5-FU was in average 28,8 mmHg (22-50 mmHg)at the end of therapy with 5-FU was 17,6 mmHg (10-30 mmHg)and in the last examination was on average 19,5 mmHg (14-28 mmHg).IOP before operation with the use of MMC was in average 30,3 mmHg (22-40 mmHg),the seventh day after administration of MMC 12,7 mmHg (6-20 mmHg)and in the last examination was in average 18 mmHg(9-28 mmHg).During the long term observation of IOP values in the 5-FU group there was 79,2%success andin the MMCgroupthere was 83,3 %success (IOPupto20 mmHgwithor without therapy).Decrease of IOP was statistically significant. Conclusion:Antimetabolites improve the success of filtering surgery in high risc glaucomas.The long term follow up shows that failure of filtration in these types of glaucomas is still a serious clinical problem.

        Key words: Glaucoma,filtering surgery,antimetabolites,Mitomycin ,5-Fluorou- racil