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CZECH MEDICAL ASSOCIATION J. Ev. PURKYNĚ |
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Česky / Czech version | Anest. neodkl. Péče, 11, 2000, No. 6, p. 267–270 |
The Effect of Continuous Veno-venous Hemofiltration on T lymphocytes and Monocytes Activation in Critically Ill Patients in Sepsis PŘÍHODOVÁ J. 4 , HOLUB M. 1 , HANZLÍKOVÁ J. 3 , MATĚJOVIČ M. 2 , ŠRÁMEK V. 2 , NOVÁK I. 2 , 1 3. klinika infekčních a tropických nemocí 1. LF UK, Praha, přednosta doc. MUDr. A. Lobovská, CSc. |
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Summary: Elimination methods can improve the prognosis of critically ill patients in sepsis. With respect to that, higher activation of monocytes during
plasmapheresis could possibly play a role (increase of HLA-DR+ monocytes in peripheral blood). We observed a decrease of T lymphocyte activation
in 19 patients after 24 hours of continuous veno-venous hemofiltration – CVVH (p < 0,01). On the third day of CVVH this activation returned to the
levels before initiating of the elimination method. Trend of monocyte activation followed the same course; however, it did not reach statistical
significance. The observed changes in the activation direct an attention to possible immunomodulatory effects of this elimination method.
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