Immunotherapy using dendritic cells develops is considered as one of the possible treatments of patients with tumour diseases in the last years. These antigen presenting cells play important role in the induction of primary immune reaction on specific antigens. Data from in vitro studies of the efficiency of vaccines of dendritic cells loaded with individual tumour RNA provides promising information and the base for further dendritic cell vaccines development. Impact of RNA-transfected cell vaccine on T-cell immunity and preparation of therapeutic anticancer responses was first studied on murine models and acquired results subsequent clinical studies on humans. Following survey summarizes studies focused on the use of RNA vaccines in tumour patients.

        Key words: dendritic cell, RNA vaccine, transfection