In 50 subjects with non-specific inflammations of the gut the total prevalence of Helicobacter pylori positive antibodies was 28%, while in the control group of blood donors it was 54 % Patients with ulcerative colitis had lower antibodies - 18%, in Crohn´s disease the serum positivity was 33 %. The lowest value of antibodies was found in patients taking Sulfasalazine - 11 %. The serum positivity was substantially higher in inactive ulcerative colitis and Crohn´s disease - 35 % than in patients with signs of high activity - 13%. In 28 patients with non-specific inflammations of the gut endoscopy was performed, in 60 % with a pathological outcome. Histologically confirmed gastritis was in the majority Helicobacter pylori negative. it may be stated that in patients with non-speci- fic inflammations of the gut there is a lower incidence of Helicobacter pylori than in the general population, in particular those subjects who were or are treated with Sulfasalazine. The explana- tion of this fact is however only speculative.

        Key words: Helicobacter pylori - Non-specific inflammations of the gut - Incidence of Helicobacter pylori infection